Pharmacogenomics in Primary Care

Explain one of the following statements in your own words. Give an example of implications for you as the prescribing primary care provider.
1. Carbamazepine has a black box warning recommending testing for the HLA-B*1502 allele in patients with Asian ancestry prior to starting therapy.
2. Testing for CYP2D6 variants prior to starting tamoxifen for breast cancer.
3. A genetic variation in how the metabolite of the cancer drug irinotecan SN-38 is inactivated by the body.